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Because the early symptoms of Paget disease of the breast may suggest a benign skin condition, and because the disease is rare, it may be misdiagnosed at first.

Moreover, it may be possible for Paget disease of the breast and tumors inside the same breast to develop independently (1).Paget disease of the breast (also known as Paget disease of the nipple and mammary Paget disease) is a rare type of cancer involving the skin of the nipple and, usually, the darker circle of skin around it, which is called the areola.Most people with Paget disease of the breast also have one or more tumors inside the same breast.In some cases, doctors may remove the entire nipple (1).A pathologist then examines the cells or tissue under a microscope to look for Paget cells.For many years, mastectomy, with or without the removal of lymph nodes under the arm on the same side of chest (known as axillary lymph node dissection), was regarded as the standard surgery for Paget disease of the breast (3, 4).

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